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يجب مراعاة ما يلي من إرشادات ومحاذير عند استخدام هذا العلاج:Systemic bacterial infections should be treated concomitantly with or maybe prior to commencing therapy with mitoxantrone.Concurrent elevations in alanine transaminase (ALT) or aspartate transaminase (AST) better than or equivalent to 3 inst